Spiros Linardopoulos
London, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 54 publications
Integration of RNAi and Small Molecule Library Screens to Identify Targets for Drug Discovery.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: March 31, 2025
Inhibition of Bromodomain Proteins Enhances Oncolytic HAdVC5 Replication and Efficacy in Pancreatic Ductal Adenocarcinoma (PDAC) Models.
Journal: International journal of molecular sciences
Published: November 05, 2023
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.
Journal: Journal of medicinal chemistry
Published: February 07, 2023
CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells.
Journal: British journal of cancer
Published: January 12, 2021
Correction: A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.
Journal: Oncogene
Published: May 20, 2020
Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: March 27, 2019
Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Published: December 05, 2018
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.
Journal: Molecular cancer therapeutics
Published: October 22, 2018
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
Journal: Journal of medicinal chemistry
Published: September 11, 2018
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Journal: Cancer discovery
Published: May 30, 2017
RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
Journal: British journal of cancer
Published: May 08, 2017
Last Updated: 09/26/2026