Stephan A. Muller

Ismaninger Str. 22
Munich, BY 81675, Germany

Last Updated: 09/26/2026

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Found 88 publications

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

Journal: Science advances
Published: February 11, 2026

Aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia.

Aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia.

Journal: Scientific reports
Published: December 03, 2025

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates.

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates.

Journal: Proteomics
Published: September 16, 2025

Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration.

Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration.

Journal: Movement disorders : official journal of the Movement Disorder Society
Published: July 17, 2025

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

Journal: EMBO reports
Published: April 25, 2025

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

Journal: Molecular neurodegeneration
Published: March 28, 2025

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype.

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype.

Journal: Journal of neuroinflammation
Published: March 17, 2025

Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress.

Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress.

Journal: The Journal of physiology
Published: January 20, 2025

Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.

Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.

Journal: Science translational medicine
Published: December 04, 2024

The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions.

The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions.

Journal: Journal of neuroinflammation
Published: November 21, 2024

Molecular insights into myelomeningocele via proteomic analysis of amniotic fluid.

Molecular insights into myelomeningocele via proteomic analysis of amniotic fluid.

Journal: Journal of proteomics
Published: October 20, 2024

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.

Journal: Nature neuroscience
Published: October 17, 2024
Showing 1-12 of 88

Last Updated: 09/26/2026