Stephane Dorich

4800 Rue Levy
Saint Laurent, QC H4R2P1, Canada

Last Updated: 09/26/2026

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Found 11 publications

Discovery of novel NLRP3 inhibitors enabled by a high-throughput screen.

Discovery of novel NLRP3 inhibitors enabled by a high-throughput screen.

Journal: Bioorganic & medicinal chemistry letters

Published: January 13, 2025

Structural insight into the cGAS active site explains differences between therapeutically relevant species.

Structural insight into the cGAS active site explains differences between therapeutically relevant species.

Journal: Communications chemistry

Published: September 22, 2024

Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).

Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).

Journal: Journal of medicinal chemistry

Published: February 01, 2024

Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease.

Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease.

Journal: Bioorganic & medicinal chemistry letters

Published: February 25, 2023

Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.

Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.

Journal: Journal of medicinal chemistry

Published: September 20, 2022

RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.

RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.

Journal: Molecular cancer therapeutics

Published: July 19, 2021

Novel pyridone EP4 agonists featuring allylic alcohol ω-chains.

Novel pyridone EP4 agonists featuring allylic alcohol ω-chains.

Journal: Bioorganic & medicinal chemistry letters

Published: January 20, 2020

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

Journal: Angewandte Chemie (International ed. in English)

Published: August 12, 2015

Concise and stereocontrolled synthesis of the tetracyclic core of daphniglaucin C.

Concise and stereocontrolled synthesis of the tetracyclic core of daphniglaucin C.

Journal: Organic letters

Published: July 30, 2013

Crystal structure of a bioactive pactamycin analog bound to the 30S ribosomal subunit.

Crystal structure of a bioactive pactamycin analog bound to the 30S ribosomal subunit.

Journal: Journal of molecular biology

Published: May 01, 2013

Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity.

Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity.

Journal: Bioorganic & medicinal chemistry

Published: December 20, 2012

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Last Updated: 09/26/2026