Stephanie Kourula

Janssen R&D
Beerse, VLG 2340, Belgium

Last Updated: 09/26/2026

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Found 12 publications

Deconvoluting the in vitro to in vivo drug clearance gap: Questioning the predictive performance of traditional hepatic clearance models.

Deconvoluting the in vitro to in vivo drug clearance gap: Questioning the predictive performance of traditional hepatic clearance models.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: November 27, 2025

Harnessing human colonoid-derived monolayers as an in vitro platform for investigating accumulation, toxicity, and pharmacodynamics of small molecules.

Harnessing human colonoid-derived monolayers as an in vitro platform for investigating accumulation, toxicity, and pharmacodynamics of small molecules.

Journal: Toxicology in vitro : an international journal published in association with BIBRA

Published: November 12, 2025

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition.

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: December 06, 2024

Toward improved clearance predictions and distribution profiles employing the isolated perfused rat liver model: Experimental optimization.

Toward improved clearance predictions and distribution profiles employing the isolated perfused rat liver model: Experimental optimization.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: November 25, 2024

Species differences in small intestinal exposure-related epithelial vacuolation in rats and dogs treated with a heteroaryldihydropyrimidine molecule.

Species differences in small intestinal exposure-related epithelial vacuolation in rats and dogs treated with a heteroaryldihydropyrimidine molecule.

Journal: Journal of applied toxicology : JAT

Published: June 22, 2023

Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.

Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: January 30, 2023

The benefits, limitations and opportunities of preclinical models for neonatal drug development.

The benefits, limitations and opportunities of preclinical models for neonatal drug development.

Journal: Disease models & mechanisms

Published: April 25, 2022

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: December 19, 2021

Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring.

Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring.

Journal: Pharmaceutics

Published: December 30, 2020

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.

Journal: Nature medicine

Published: August 28, 2019

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

Journal: Nature communications

Published: April 13, 2018

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

Journal: Nature

Published: February 16, 2014

Showing 1-12 of 12

Last Updated: 09/26/2026