Last Updated: 09/26/2026
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Found 33 publications
Taming the "death receptor": translating the first-in-class p75NTR modulator LM11A-31 from basic biology, across broad preclinical models, to clinical proof-of-concept.
Journal: Journal of translational medicine
Published: January 28, 2026
Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation.
Journal: Acta neuropathologica communications
Published: September 15, 2025
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial.
Journal: Nature medicine
Published: November 01, 2023
Targeting Endogenous Mechanisms of Brain Resilience for the Treatment and Prevention of Alzheimer's Disease.
Journal: The journal of prevention of Alzheimer's disease
Published: October 24, 2023
Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke.
Journal: Biomolecules
Published: January 27, 2023
Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage.
Journal: Neurobiology of disease
Published: July 13, 2021
Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media.
Journal: NPJ biofilms and microbiomes
Published: August 18, 2020
Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.
Journal: Acta neuropathologica communications
Published: July 14, 2020
Editorial: Next-Generation Alzheimer's Therapeutics: Leveraging Deep Biology.
Journal: The journal of prevention of Alzheimer's disease
Published: May 29, 2020
Last Updated: 09/26/2026