Stephen Neidle

London, ENG WC1N1AX, United Kingdom

Last Updated: 09/26/2026

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Found 90 publications

DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC.

DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC.

Journal: Genome biology

Published: August 20, 2025

Structural and Functional Insights into Targeting GCCG Sites in the EGFR Promoter by Two DNA Intercalators to Inhibit Breast Cancer Metastasis.

Structural and Functional Insights into Targeting GCCG Sites in the EGFR Promoter by Two DNA Intercalators to Inhibit Breast Cancer Metastasis.

Journal: Journal of medicinal chemistry

Published: March 03, 2025

Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence.

Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence.

Journal: ACS chemical biology

Published: February 07, 2025

Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells.

Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells.

Journal: Cell death & disease

Published: November 11, 2024

The G-quadruplex experimental drug QN-302 impairs liposarcoma cell growth by inhibiting MDM2 expression and restoring p53 levels.

The G-quadruplex experimental drug QN-302 impairs liposarcoma cell growth by inhibiting MDM2 expression and restoring p53 levels.

Journal: Nucleic acids research

Published: July 29, 2024

A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs.

A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs.

Journal: Molecules (Basel, Switzerland)

Published: July 17, 2024

Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene.

Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene.

Journal: Nucleic acids research

Published: July 05, 2024

Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation.

Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation.

Journal: Nucleic acids research

Published: January 25, 2024

On Water Arrangements in Right- and Left-Handed DNA Structures.

On Water Arrangements in Right- and Left-Handed DNA Structures.

Journal: Molecules (Basel, Switzerland)

Published: December 13, 2023

Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling.

Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling.

Journal: Scientific reports

Published: November 21, 2023

QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene.

QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene.

Journal: Organic & biomolecular chemistry

Published: November 16, 2023

On the origins of the conflict between Rosalind Franklin and Maurice Wilkins.

On the origins of the conflict between Rosalind Franklin and Maurice Wilkins.

Journal: Nature reviews. Chemistry

Published: October 12, 2023

Showing 1-12 of 90

Last Updated: 09/26/2026