Steven Havlicek

Singapore, Singapore

Last Updated: 09/26/2026

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Found 13 publications

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.

Journal: EBioMedicine

Published: February 02, 2023

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Journal: Molecular psychiatry

Published: July 17, 2021

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Journal: Molecular psychiatry

Published: January 29, 2020

A Balanced Translocation in Kallmann Syndrome Implicates a Long Noncoding RNA, RMST, as a GnRH Neuronal Regulator.

A Balanced Translocation in Kallmann Syndrome Implicates a Long Noncoding RNA, RMST, as a GnRH Neuronal Regulator.

Journal: The Journal of clinical endocrinology and metabolism

Published: August 30, 2019

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: July 12, 2018

Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells.

Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: July 14, 2016

GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient induced pluripotent stem cell model.

GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient induced pluripotent stem cell model.

Journal: Annals of neurology

Published: September 10, 2015

Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling.

Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling.

Journal: Molecular neurobiology

Published: May 11, 2015

Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors.

Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors.

Journal: Stem cell reports

Published: November 03, 2014

Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia.

Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia.

Journal: Human molecular genetics

Published: May 06, 2014

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.

Journal: Human molecular genetics

Published: January 02, 2014

Role of Na(v)1.9 in activity-dependent axon growth in motoneurons.

Role of Na(v)1.9 in activity-dependent axon growth in motoneurons.

Journal: Human molecular genetics

Published: May 30, 2012

Showing 1-12 of 13

Last Updated: 09/26/2026