Last Updated: 09/26/2026
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Found 18 publications
A chaperonin complex regulates organelle proteostasis in malaria parasites.
Journal: PLoS pathogens
Published: December 03, 2024
Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1.
Journal: Protein science : a publication of the Protein Society
Published: May 25, 2024
Discovery of a Tunable Heterocyclic Electrophile 4-Chloro-pyrazolopyridine That Defines a Unique Subset of Ligandable Cysteines.
Journal: ACS chemical biology
Published: April 17, 2024
Chemically induced partial unfolding of the multifunctional Apurinic/apyrimidinic endonuclease 1.
Journal: bioRxiv : the preprint server for biology
Published: July 10, 2023
Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.
Journal: Bioorganic & medicinal chemistry
Published: August 29, 2022
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Journal: Bioorganic & medicinal chemistry
Published: January 28, 2021
Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL.
Journal: mBio
Published: January 13, 2021
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Journal: Bioorganic & medicinal chemistry
Published: July 02, 2020
A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
Journal: Bioorganic & medicinal chemistry letters
Published: March 14, 2019
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Journal: Bioorganic & medicinal chemistry letters
Published: March 11, 2019
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
Journal: Bioorganic & medicinal chemistry letters
Published: December 11, 2018
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.
Journal: Journal of medicinal chemistry
Published: November 06, 2018
Last Updated: 09/26/2026