Last Updated: 09/26/2026
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Found 20 publications
Novel histone deacetylase inhibitor CT-101 induces γ-globin gene expression in sickle erythroid progenitors with targeted epigenetic effects.
Journal: Blood cells, molecules & diseases
Published: October 05, 2021
Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
Journal: Blood cells, molecules & diseases
Published: December 11, 2020
An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.
Journal: Blood cells, molecules & diseases
Published: September 28, 2016
Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer.
Journal: American journal of hematology
Published: September 27, 2016
Sleep-disordered breathing and nocturnal hypoxemia in young adults with sickle cell disease.
Journal: Sleep medicine
Published: February 16, 2016
Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.
Journal: Blood cells, molecules & diseases
Published: October 16, 2015
Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.
Journal: PloS one
Published: August 24, 2015
A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia.
Journal: Blood
Published: March 22, 2014
Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies.
Journal: Hematology/oncology clinics of North America
Published: March 05, 2014
A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in β-thalassaemia intermedia.
Journal: British journal of haematology
Published: November 15, 2013
A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.
Journal: American journal of hematology
Published: May 08, 2013
Last Updated: 09/26/2026