Sven N. Hobbie

Zurich, ZH, Switzerland

Last Updated: 09/26/2026

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Found 43 publications

Gentamicin triggers fatty acid oxidation-dependent mitochondrial ROS, driving greater nephrotoxicity than apramycin and other aminoglycosides.

Gentamicin triggers fatty acid oxidation-dependent mitochondrial ROS, driving greater nephrotoxicity than apramycin and other aminoglycosides.

Journal: Free radical biology & medicine

Published: December 10, 2025

G1405 Ribosomal Methyltransferase-Driven Antibacterial Resistance Affects the 4,5-Disubstituted-2-deoxystreptamine Class of Aminoglycoside Antibiotics.

G1405 Ribosomal Methyltransferase-Driven Antibacterial Resistance Affects the 4,5-Disubstituted-2-deoxystreptamine Class of Aminoglycoside Antibiotics.

Journal: JACS Au

Published: October 14, 2025

Multicentre preclinical profiling of apramycin for the treatment of nontuberculous mycobacteria.

Multicentre preclinical profiling of apramycin for the treatment of nontuberculous mycobacteria.

Journal: EBioMedicine

Published: March 08, 2025

Synthesis of Methyl Aprabiosaminide and 2-Hydroxyapramycin from Apramycin.

Synthesis of Methyl Aprabiosaminide and 2-Hydroxyapramycin from Apramycin.

Journal: Organic letters

Published: February 14, 2025

Phenotypic Differentiation Within the aac(6') Aminoglycoside Resistance Gene Family Suggests a Novel Subtype IV of Contemporary Clinical Relevance.

Phenotypic Differentiation Within the aac(6') Aminoglycoside Resistance Gene Family Suggests a Novel Subtype IV of Contemporary Clinical Relevance.

Journal: Antibiotics (Basel, Switzerland)

Published: November 17, 2024

Correction: Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.

Correction: Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.

Journal: The Journal of antibiotics

Published: October 11, 2024

Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus.

Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus.

Journal: Nature microbiology

Published: September 12, 2024

Pharmacodynamic assessment of apramycin against Mycobacterium abscessus in a hollow fibre infection model.

Pharmacodynamic assessment of apramycin against Mycobacterium abscessus in a hollow fibre infection model.

Journal: The Journal of antimicrobial chemotherapy

Published: July 15, 2024

Evaluation of the Allplex NG & DR assay for molecular prediction of ciprofloxacin and azithromycin resistance in Neisseria gonorrhoeae.

Evaluation of the Allplex NG & DR assay for molecular prediction of ciprofloxacin and azithromycin resistance in Neisseria gonorrhoeae.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Published: July 04, 2024

Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections.

Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections.

Journal: The Journal of antimicrobial chemotherapy

Published: May 13, 2024

Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.

Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.

Journal: The Journal of antibiotics

Published: April 01, 2024

L-carnitine co-administration prevents colistin-induced mitochondrial permeability transition and reduces the risk of acute kidney injury in mice.

L-carnitine co-administration prevents colistin-induced mitochondrial permeability transition and reduces the risk of acute kidney injury in mice.

Journal: Scientific reports

Published: February 22, 2024

Showing 1-12 of 43

Last Updated: 09/26/2026