Sven Van Brandt

Beerse, VLG, Belgium

Last Updated: 09/26/2026

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Found 13 publications

An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target.

An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target.

Journal: PLoS pathogens

Published: December 29, 2025

Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.

Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.

Journal: Journal of medicinal chemistry

Published: August 26, 2025

Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration.

Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration.

Journal: Journal of medicinal chemistry

Published: February 17, 2025

Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

Journal: European journal of medicinal chemistry

Published: September 03, 2021

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

Journal: ACS medicinal chemistry letters

Published: August 18, 2021

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.

Journal: ACS medicinal chemistry letters

Published: April 19, 2019

Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.

Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.

Journal: Bioorganic & medicinal chemistry letters

Published: March 18, 2019

Correction to Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Correction to Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Journal: Journal of medicinal chemistry

Published: December 12, 2018

Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Journal: Journal of medicinal chemistry

Published: May 29, 2018

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.

Journal: Journal of medicinal chemistry

Published: September 18, 2015

Anilinotriazoles as potent gamma secretase modulators.

Anilinotriazoles as potent gamma secretase modulators.

Journal: Bioorganic & medicinal chemistry letters

Published: August 29, 2014

Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.

Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.

Journal: Bioorganic & medicinal chemistry letters

Published: June 18, 2013

Showing 1-12 of 13

Last Updated: 09/26/2026