Svetla G. Taneva
Burnaby, BC V5A1S6, Canada
Last Updated: 09/26/2026
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Found 9 publications
Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix.
Journal: The Journal of biological chemistry
Published: June 18, 2019
Remodeling of the interdomain allosteric linker upon membrane binding of CCTα pulls its active site close to the membrane surface.
Journal: The Journal of biological chemistry
Published: June 18, 2019
Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stability.
Journal: The Journal of biological chemistry
Published: October 26, 2018
An auto-inhibitory helix in CTP:phosphocholine cytidylyltransferase hijacks the catalytic residue and constrains a pliable, domain-bridging helix pair.
Journal: The Journal of biological chemistry
Published: January 23, 2018
Structural basis for autoinhibition of CTP:phosphocholine cytidylyltransferase (CCT), the regulatory enzyme in phosphatidylcholine synthesis, by its membrane-binding amphipathic helix.
Journal: The Journal of biological chemistry
Published: November 27, 2013
The membrane-binding domain of an amphitropic enzyme suppresses catalysis by contact with an amphipathic helix flanking its active site.
Journal: Journal of molecular biology
Published: October 04, 2012
A 22-mer segment in the structurally pliable regulatory domain of metazoan CTP: phosphocholine cytidylyltransferase facilitates both silencing and activating functions.
Journal: The Journal of biological chemistry
Published: September 19, 2012
The amphipathic helix of an enzyme that regulates phosphatidylcholine synthesis remodels membranes into highly curved nanotubules.
Journal: Biochimica et biophysica acta
Published: November 23, 2011
Showing 1-9 of 9
Last Updated: 09/26/2026