Sylvain A. Jacques

Illkirch-graffenstaden, France

Last Updated: 09/26/2026

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Found 13 publications

Novel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature.

Novel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature.

Journal: Beilstein journal of organic chemistry

Published: October 21, 2020

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

Journal: PLoS pathogens

Published: January 04, 2020

Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.

Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.

Journal: ACS chemical biology

Published: May 09, 2017

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Journal: Nature

Published: April 28, 2017

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Journal: Cell reports

Published: December 24, 2016

From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release.

From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release.

Journal: Organic & biomolecular chemistry

Published: May 13, 2016

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.

Journal: Journal of medicinal chemistry

Published: January 16, 2016

Spiro Diorthoester (SpiDo), a Human Plasma Stable Acid-Sensitive Cleavable Linker for Lysosomal Release.

Spiro Diorthoester (SpiDo), a Human Plasma Stable Acid-Sensitive Cleavable Linker for Lysosomal Release.

Journal: Bioconjugate chemistry

Published: July 02, 2015

Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.

Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.

Journal: Journal of medicinal chemistry

Published: March 25, 2015

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Journal: Cell reports

Published: January 23, 2015

Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.

Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: December 18, 2014

Chemical strategies for development of ATR inhibitors.

Chemical strategies for development of ATR inhibitors.

Journal: Expert reviews in molecular medicine

Published: May 09, 2014

Showing 1-12 of 13

Last Updated: 09/26/2026