Sylvie Ducki

Clermont-ferrand, 63000, France

Last Updated: 09/26/2026

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Found 10 publications

LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening.

LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening.

Journal: Biomolecules

Published: March 31, 2025

Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA).

Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA).

Journal: European journal of medicinal chemistry

Published: July 21, 2022

TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects.

TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects.

Journal: British journal of pharmacology

Published: October 28, 2019

Optimization of the synthesis of a key intermediate for the preparation of glucocorticoids.

Optimization of the synthesis of a key intermediate for the preparation of glucocorticoids.

Journal: Steroids

Published: February 15, 2018

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.

Journal: Journal of medicinal chemistry

Published: January 05, 2017

Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?

Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?

Journal: Journal of medicinal chemistry

Published: November 21, 2015

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions.

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions.

Journal: Scientific reports

Published: March 05, 2015

Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.

Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.

Journal: European journal of medicinal chemistry

Published: October 16, 2013

Structure-based design of PDZ ligands as inhibitors of 5-HT(2A) receptor/PSD-95 PDZ1 domain interaction possessing anti-hyperalgesic activity.

Structure-based design of PDZ ligands as inhibitors of 5-HT(2A) receptor/PSD-95 PDZ1 domain interaction possessing anti-hyperalgesic activity.

Journal: ACS chemical biology

Published: July 31, 2013

Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents.

Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents.

Journal: Bioorganic & medicinal chemistry letters

Published: February 07, 2013

Showing 1-10 of 10

Last Updated: 09/26/2026