Sylvie Grosch-Dirrig

Strasbourg, France

Last Updated: 09/26/2026

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Found 19 publications

CREB3 gain of function variants protect against ALS.

CREB3 gain of function variants protect against ALS.

Journal: Nature communications

Published: May 09, 2024

Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency.

Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency.

Journal: Science translational medicine

Published: March 13, 2024

Author Correction: Integrative genetic analysis illuminates ALS heritability and identifies risk genes.

Author Correction: Integrative genetic analysis illuminates ALS heritability and identifies risk genes.

Journal: Nature communications

Published: December 04, 2023

Alteration of the Neuromuscular Junction and Modifications of Muscle Metabolism in Response to Neuron-Restricted Expression of the CHMP2Bintron5 Mutant in a Mouse Model of ALS-FTD Syndrome.

Alteration of the Neuromuscular Junction and Modifications of Muscle Metabolism in Response to Neuron-Restricted Expression of the CHMP2Bintron5 Mutant in a Mouse Model of ALS-FTD Syndrome.

Journal: Biomolecules

Published: December 14, 2021

Integrative genetic analysis illuminates ALS heritability and identifies risk genes.

Integrative genetic analysis illuminates ALS heritability and identifies risk genes.

Journal: Nature communications

Published: August 08, 2021

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.

Journal: Molecular neurodegeneration

Published: May 11, 2021

Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism.

Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism.

Journal: Progress in neurobiology

Published: July 28, 2020

Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.

Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.

Journal: Nature communications

Published: May 25, 2020

Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD.

Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD.

Journal: Neurobiology of disease

Published: February 05, 2019

Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis.

Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis.

Journal: Annals of neurology

Published: May 10, 2017

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.

Journal: Acta neuropathologica

Published: December 15, 2016

A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.

A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.

Journal: Human molecular genetics

Published: February 05, 2016

Showing 1-12 of 19

Last Updated: 09/26/2026