Last Updated: 09/26/2026
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Found 6 publications
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex.
Journal: Nature communications
Published: April 02, 2022
Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15.
Journal: Cell reports
Published: June 06, 2019
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Journal: Nature
Published: September 10, 2017
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Journal: PLoS genetics
Published: April 04, 2017
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Journal: Science (New York, N.Y.)
Published: November 09, 2016
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Last Updated: 09/26/2026