Taebo Sim

Taebo Sim

Seoul, Republic of Korea

Last Updated: 09/26/2026

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Found 102 publications

Progress and challenges in the design and development of selective KRAS G12D-targeted drug discovery: inhibitors, degraders and emerging therapeutic strategies.

Progress and challenges in the design and development of selective KRAS G12D-targeted drug discovery: inhibitors, degraders and emerging therapeutic strategies.

Journal: Future medicinal chemistry

Published: August 19, 2026

Identification of RET PROTAC with excellent degradation efficiency against medullary thyroid carcinoma.

Identification of RET PROTAC with excellent degradation efficiency against medullary thyroid carcinoma.

Journal: European journal of medicinal chemistry

Published: January 07, 2026

Selective CDK6 Degradation via the KLHDC2 E3 Ubiquitin Ligase.

Selective CDK6 Degradation via the KLHDC2 E3 Ubiquitin Ligase.

Journal: Journal of medicinal chemistry

Published: December 02, 2025

PHI-501, a dual inhibitor of RAF and DDR1/2, overcomes MAPK drug resistance in Melanoma.

PHI-501, a dual inhibitor of RAF and DDR1/2, overcomes MAPK drug resistance in Melanoma.

Journal: Cancer cell international

Published: September 30, 2025

Editor's Note: Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer.

Editor's Note: Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: August 29, 2025

Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress.

Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress.

Journal: Theranostics

Published: May 28, 2025

Identification of Novel Oxazolo[5,4-d]pyrimidines as IL-33 Inhibitors for Immuno-Oncology Therapy.

Identification of Novel Oxazolo[5,4-d]pyrimidines as IL-33 Inhibitors for Immuno-Oncology Therapy.

Journal: Chembiochem : a European journal of chemical biology

Published: May 25, 2025

Unraveling the Mode of Action of a Neuron-Specific Fluorescent Probe, NeuO: Intracellular Phosphorylation Through PAK6 Kinase.

Unraveling the Mode of Action of a Neuron-Specific Fluorescent Probe, NeuO: Intracellular Phosphorylation Through PAK6 Kinase.

Journal: Angewandte Chemie (International ed. in English)

Published: May 21, 2025

KRASG12D selective VHL-PROTAC with sparing KRASWT and other KRAS mutants.

KRASG12D selective VHL-PROTAC with sparing KRASWT and other KRAS mutants.

Journal: European journal of medicinal chemistry

Published: May 10, 2025

Synthesis and biological evaluation of α-D-tocopherol derivatives as anticancer agents targeting mitochondrial metabolism.

Synthesis and biological evaluation of α-D-tocopherol derivatives as anticancer agents targeting mitochondrial metabolism.

Journal: European journal of medicinal chemistry

Published: May 02, 2025

Apomorphine is a novel necroptosis inhibitor targeting mixed lineage kinase domain-like protein oligomerization.

Apomorphine is a novel necroptosis inhibitor targeting mixed lineage kinase domain-like protein oligomerization.

Journal: Cell death discovery

Published: March 07, 2025

Identification of Thieno[3,2-d]pyrimidine derivatives as potent and selective Janus Kinase 1 inhibitors.

Identification of Thieno[3,2-d]pyrimidine derivatives as potent and selective Janus Kinase 1 inhibitors.

Journal: European journal of medicinal chemistry

Published: November 18, 2024

Showing 1-12 of 102

Last Updated: 09/26/2026