Taira Kiyota

Toronto, ON M5G0A3, Canada

Last Updated: 09/26/2026

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Found 27 publications

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Journal: Journal of medicinal chemistry

Published: June 22, 2026

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

Journal: Journal of medicinal chemistry

Published: May 18, 2026

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

Journal: European journal of medicinal chemistry

Published: January 27, 2026

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Journal: Bioorganic & medicinal chemistry

Published: December 16, 2025

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: October 27, 2025

A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry.

A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry.

Journal: Neuro-oncology

Published: February 21, 2025

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

Journal: Communications biology

Published: January 17, 2025

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Journal: Nature communications

Published: May 22, 2024

Discovery of Conformationally Constrained ALK2 Inhibitors.

Discovery of Conformationally Constrained ALK2 Inhibitors.

Journal: Journal of medicinal chemistry

Published: March 18, 2024

A Workflow for Meaningful Interpretation of Classification Results from Handheld Ambient Mass Spectrometry Analysis Probes.

A Workflow for Meaningful Interpretation of Classification Results from Handheld Ambient Mass Spectrometry Analysis Probes.

Journal: International journal of molecular sciences

Published: January 23, 2024

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.

Journal: ACS medicinal chemistry letters

Published: November 30, 2022

Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.

Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.

Journal: Cell chemical biology

Published: June 03, 2022

Showing 1-12 of 27

Last Updated: 09/26/2026