Takaaki Miura

Kamakura, 2478530, Japan

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 12 publications

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.

Journal: Scientific reports

Published: December 21, 2016

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD).

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD).

Journal: Chemical & pharmaceutical bulletin

Published: November 03, 2016

Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries.

Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries.

Journal: Bioorganic & medicinal chemistry letters

Published: October 08, 2016

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD).

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD).

Journal: Bioorganic & medicinal chemistry

Published: May 27, 2016

Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors.

Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: October 04, 2013

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

Journal: Cancer cell

Published: August 29, 2013

Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.

Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.

Journal: Cancer research

Published: May 14, 2013

Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors.

Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: August 17, 2012

Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers.

Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers.

Journal: Cancer science

Published: November 05, 2011

Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.

Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: October 11, 2011

Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.

Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.

Journal: Bioorganic & medicinal chemistry letters

Published: June 04, 2011

Fragment screening using surface plasmon resonance optical biosensor technology

Fragment screening using surface plasmon resonance optical biosensor technology

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Published: March 02, 2010

Showing 1-12 of 12

Last Updated: 09/26/2026