Takafumi Hiramoto
Tochigi, Japan
Last Updated: 09/26/2026
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Found 15 publications
Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation.
Journal: Nature communications
Published: September 14, 2025
Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B.
Journal: Blood
Published: November 30, 2024
Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology
Published: November 07, 2024
Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy.
Journal: Molecular therapy. Methods & clinical development
Published: February 17, 2023
Application of genome editing technology in gene therapy
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology
Published: December 08, 2022
Successful liver transduction by re-administration of different adeno-associated virus vector serotypes in mice.
Journal: The journal of gene medicine
Published: October 23, 2022
The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs.
Journal: Molecular therapy. Methods & clinical development
Published: June 21, 2022
Characterization and visualization of murine coagulation factor VIII-producing cells in vivo.
Journal: Scientific reports
Published: April 20, 2021
PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells.
Journal: Communications medicine
Published: February 23, 2021
A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid.
Journal: Molecular therapy. Methods & clinical development
Published: January 28, 2021
Last Updated: 09/26/2026