Takafumi Komori
Tsukuba, Japan
Last Updated: 09/26/2026
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Found 16 publications
Structure and properties of an oxidative metabolite of 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide generated by aldehyde oxidase.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: July 10, 2025
Functional assessment of immortalized human brain microvascular endothelial cells with different passage numbers: A case study for a prospective proposal on variability management of in vitro blood-brain barrier models.
Journal: Drug metabolism and pharmacokinetics
Published: September 12, 2024
Determination of drug-to-antibody ratio of antibody-drug conjugate in biological samples using microflow-liquid chromatography/high-resolution mass spectrometry.
Journal: Bioanalysis
Published: February 24, 2023
Human Immortalized Cell-Based Blood-Brain Barrier Spheroid Models Offer an Evaluation Tool for the Brain Penetration Properties of Macromolecules.
Journal: Molecular pharmaceutics
Published: June 29, 2022
In Vitro Metabolism of 2-Methoxy-N-[3-[4-[3-methyl-4-[(6-methyl- 3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide (CP-724,714) by Aldehyde Oxidase and Predicting Its Percent Contribution Relative to CYP-Mediated Metabolism.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: June 15, 2022
In Vitro-In Vivo Correlation of Blood-Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans.
Journal: Pharmaceutical research
Published: November 29, 2021
Development, Characterization and Potential Applications of a Multicellular Spheroidal Human Blood-Brain Barrier Model Integrating Three Conditionally Immortalized Cell Lines.
Journal: Biological & pharmaceutical bulletin
Published: April 26, 2021
Bioactivation of diclofenac in human hepatocytes and the proposed human hepatic proteins modified by reactive metabolites.
Journal: Xenobiotica; the fate of foreign compounds in biological systems
Published: February 11, 2020
Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.
Journal: Molecular pharmaceutics
Published: January 22, 2020
A Human Immortalized Cell-Based Blood-Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug-Brain Permeability Studies.
Journal: Molecular pharmaceutics
Published: October 02, 2019
Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.
Journal: Molecular pharmaceutics
Published: May 11, 2018
Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.
Journal: Journal of pharmaceutical sciences
Published: December 26, 2016
Last Updated: 09/26/2026