Takahiko Yamamoto

Toyonaka, 5610825, Japan

Last Updated: 09/26/2026

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Found 24 publications

Electrical Property Enhancement of a Breast-Fat-Equivalent Phantom for Microwave Mammography.

Electrical Property Enhancement of a Breast-Fat-Equivalent Phantom for Microwave Mammography.

Journal: Bioengineering (Basel, Switzerland)
Published: March 12, 2026

Transcutaneous Energy Transmission System for a Totally Implantable Artificial Heart Using a Two-Wire Archimedean Spiral Coil.

Transcutaneous Energy Transmission System for a Totally Implantable Artificial Heart Using a Two-Wire Archimedean Spiral Coil.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Published: December 11, 2021

Prototype and Evaluation of High-Hydrous Gel Phantom for 100 kHz to 1 MHz Using ATO/TiO2.

Prototype and Evaluation of High-Hydrous Gel Phantom for 100 kHz to 1 MHz Using ATO/TiO2.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Published: December 11, 2021

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.

Journal: Journal of medicinal chemistry
Published: March 15, 2021

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.

Journal: Journal of medicinal chemistry
Published: February 16, 2021

Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction.

Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction.

Journal: European journal of medicinal chemistry
Published: October 18, 2020

Development of a high-hydrous gel phantom for human body communication based on electrical anisotropy.

Development of a high-hydrous gel phantom for human body communication based on electrical anisotropy.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Published: January 18, 2020

Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

Journal: Journal of medicinal chemistry
Published: September 25, 2019

Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden.

Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden.

Journal: ChemMedChem
Published: August 17, 2019

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.

Journal: Journal of medicinal chemistry
Published: April 26, 2019

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.

Journal: Journal of medicinal chemistry
Published: May 19, 2018

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.

Journal: Journal of medicinal chemistry
Published: May 08, 2018
Showing 1-12 of 24

Last Updated: 09/26/2026