Takashi Higuchi
Minato, Japan
Last Updated: 09/26/2026
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Found 27 publications
Adeno-associated virus expressing a blood-brain barrier-penetrating enzyme improves GM1 gangliosidosis in a preclinical model.
Journal: The Journal of clinical investigation
Published: March 04, 2024
Restoration of peripheral neuropathy in Fabry mice via intrathecal administration of an adeno-associated virus vector encoding mGLA cDNA.
Journal: Molecular genetics and metabolism
Published: March 01, 2024
Erratum: Hematopoietic stem cell gene therapy ameliorates CNS involvement in murine model of GM1-gangliosidosis.
Journal: Molecular therapy. Methods & clinical development
Published: October 03, 2022
Promoter considerations in the design of lentiviral vectors for use in treating lysosomal storage diseases.
Journal: Molecular therapy. Methods & clinical development
Published: January 03, 2022
Hematopoietic stem cell gene therapy ameliorates CNS involvement in murine model of GM1-gangliosidosis.
Journal: Molecular therapy. Methods & clinical development
Published: November 30, 2021
Efficient engraftment of genetically modified cells is necessary to ameliorate central nervous system involvement of murine model of mucopolysaccharidosis type II by hematopoietic stem cell targeted gene therapy.
Journal: Molecular genetics and metabolism
Published: April 10, 2020
Mutation spectrum of α-Galactosidase gene in Japanese patients with Fabry disease.
Journal: Journal of human genetics
Published: December 19, 2018
Chaperone effect of sulfated disaccharide from heparin on mutant iduronate-2-sulfatase in mucopolysaccharidosis type II.
Journal: Molecular genetics and metabolism
Published: October 28, 2017
Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II.
Journal: Molecular genetics and metabolism
Published: June 14, 2016
TFEB overexpression promotes glycogen clearance of Pompe disease iPSC-derived skeletal muscle.
Journal: Molecular therapy. Methods & clinical development
Published: March 07, 2016
Metabolomic Profiling of Pompe Disease-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals That Oxidative Stress Is Associated with Cardiac and Skeletal Muscle Pathology.
Journal: Stem cells translational medicine
Published: December 20, 2015
Last Updated: 09/26/2026