Takashi Umehara

Kusatsu, 5258577, Japan

Last Updated: 09/26/2026

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Found 65 publications

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture.

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture.

Journal: Science advances

Published: November 19, 2025

Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics.

Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics.

Journal: Communications biology

Published: June 11, 2025

Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state.

Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state.

Journal: European journal of medicinal chemistry

Published: February 16, 2025

Discovery of potent substrate-type lysine methyltransferase G9a inhibitors for the treatment of sickle cell disease.

Discovery of potent substrate-type lysine methyltransferase G9a inhibitors for the treatment of sickle cell disease.

Journal: European journal of medicinal chemistry

Published: January 27, 2025

Discovery of a novel class NSD2 inhibitor for multiple myeloma with t(4;14).

Discovery of a novel class NSD2 inhibitor for multiple myeloma with t(4;14).

Journal: Blood neoplasia

Published: August 20, 2024

Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice.

Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice.

Journal: PLoS biology

Published: July 30, 2024

Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment.

Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment.

Journal: Bioorganic & medicinal chemistry letters

Published: April 24, 2024

Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma.

Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma.

Journal: Cancer gene therapy

Published: March 12, 2024

Polycomb-mediated histone modifications and gene regulation.

Polycomb-mediated histone modifications and gene regulation.

Journal: Biochemical Society transactions

Published: November 14, 2023

GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.

GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: October 16, 2023

Efficiency of transcription and translation of cell-free protein synthesis systems in cell-sized lipid vesicles with changing lipid composition determined by fluorescence measurements.

Efficiency of transcription and translation of cell-free protein synthesis systems in cell-sized lipid vesicles with changing lipid composition determined by fluorescence measurements.

Journal: Scientific reports

Published: October 13, 2023

Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties.

Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties.

Journal: BMC genomics

Published: July 26, 2023

Showing 1-12 of 65

Last Updated: 09/26/2026