Takashi Yoshinaga

Tsukuba, Japan

Last Updated: 09/26/2026

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Found 28 publications

Detection of seizurogenic compounds in human and rat neurons in vitro: A multi-laboratory, multi-model assessment.

Detection of seizurogenic compounds in human and rat neurons in vitro: A multi-laboratory, multi-model assessment.

Journal: Neurotoxicology

Published: April 27, 2026

In vitro and preclinical assessment of drug interactions between fluoroquinolones and a nonsteroidal antiinflammatory drug predicting risk of seizure.

In vitro and preclinical assessment of drug interactions between fluoroquinolones and a nonsteroidal antiinflammatory drug predicting risk of seizure.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: March 26, 2026

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Journal: Nature

Published: November 29, 2025

Advanced cardiotoxicity profiling using field potential imaging with UHD-CMOS-MEA in human iPSC-derived cardiomyocytes.

Advanced cardiotoxicity profiling using field potential imaging with UHD-CMOS-MEA in human iPSC-derived cardiomyocytes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: September 30, 2025

In vitro seizure risk assessment using a microelectrode array and comparison with an in vivo rat study.

In vitro seizure risk assessment using a microelectrode array and comparison with an in vivo rat study.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: April 24, 2025

Results from an EFPIA, JPMA, PhRMA industry survey on reopening and revamping the ICH S7A guidance on safety and secondary pharmacology.

Results from an EFPIA, JPMA, PhRMA industry survey on reopening and revamping the ICH S7A guidance on safety and secondary pharmacology.

Journal: Journal of pharmacological and toxicological methods

Published: March 04, 2025

Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion.

Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion.

Journal: The Journal of toxicological sciences

Published: September 04, 2024

Contractility assessment using aligned human iPSC-derived cardiomyocytes.

Contractility assessment using aligned human iPSC-derived cardiomyocytes.

Journal: Journal of pharmacological and toxicological methods

Published: February 08, 2024

Cardiovascular safety pharmacology: in vitro strategies and improvements in technology and evaluation

Cardiovascular safety pharmacology: in vitro strategies and improvements in technology and evaluation

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica

Published: September 02, 2021

Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID-19: A simulation study.

Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID-19: A simulation study.

Journal: Clinical and translational science

Published: October 27, 2020

Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.

Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.

Journal: Clinical pharmacology and therapeutics

Published: June 02, 2020

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Journal: Clinical pharmacology and therapeutics

Published: June 24, 2019

Showing 1-12 of 28

Last Updated: 09/26/2026