Tatsuki Koike

Kanagawa, Japan

Last Updated: 09/26/2026

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Found 34 publications

In vivo quantitative assessments with [11C]T-278, a PET imaging agent for diacylglycerol kinase gamma, in nonhuman primate brain.

In vivo quantitative assessments with [11C]T-278, a PET imaging agent for diacylglycerol kinase gamma, in nonhuman primate brain.

Journal: NeuroImage

Published: November 18, 2025

Preclinical characterization of pharmacokinetics, enzyme occupancy, and pharmacodynamics of soticlestat (TAK-935), a novel cholesterol 24-hydroxylase inhibitor.

Preclinical characterization of pharmacokinetics, enzyme occupancy, and pharmacodynamics of soticlestat (TAK-935), a novel cholesterol 24-hydroxylase inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics

Published: September 30, 2025

Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme-iron binding group.

Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme-iron binding group.

Journal: Bioorganic & medicinal chemistry

Published: May 16, 2025

Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors.

Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: March 12, 2025

An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions.

An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions.

Journal: Current biology : CB

Published: November 15, 2024

Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection.

Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection.

Journal: Angewandte Chemie (International ed. in English)

Published: June 23, 2024

TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models.

TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models.

Journal: Scientific reports

Published: May 15, 2024

Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal motoneurons in rodents.

Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal motoneurons in rodents.

Journal: PloS one

Published: March 11, 2024

Effects of an OX2R agonist on migration and removal of tau from mouse brain.

Effects of an OX2R agonist on migration and removal of tau from mouse brain.

Journal: Scientific reports

Published: February 22, 2024

Reply to: The G protein preference of orexin receptors is currently an unresolved issue.

Reply to: The G protein preference of orexin receptors is currently an unresolved issue.

Journal: Nature communications

Published: January 15, 2023

TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy.

TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy.

Journal: The Journal of pharmacology and experimental therapeutics

Published: September 15, 2022

Deep Learning-Based Seminal Vesicle and Vas Deferens Recognition in the Posterior Approach of Robot-Assisted Radical Prostatectomy.

Deep Learning-Based Seminal Vesicle and Vas Deferens Recognition in the Posterior Approach of Robot-Assisted Radical Prostatectomy.

Journal: Urology

Published: September 01, 2022

Showing 1-12 of 34

Last Updated: 09/26/2026