Tatsuo Akaki

Takatsuki, 5691125, Japan

Last Updated: 09/26/2026

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Found 8 publications

Identification of AMPD2 allosteric inhibitors with novel mechanism of action by fragment merging approach.

Identification of AMPD2 allosteric inhibitors with novel mechanism of action by fragment merging approach.

Journal: SLAS discovery : advancing life sciences R & D

Published: November 30, 2025

Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.

Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.

Journal: Biochemistry

Published: July 06, 2023

Fragment Molecular Orbital Based Affinity Prediction toward Pyruvate Dehydrogenase Kinases: Insights into the Charge Transfer in Hydrogen Bond Networks.

Fragment Molecular Orbital Based Affinity Prediction toward Pyruvate Dehydrogenase Kinases: Insights into the Charge Transfer in Hydrogen Bond Networks.

Journal: Chemical & pharmaceutical bulletin

Published: February 01, 2023

The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action.

The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action.

Journal: Bioorganic & medicinal chemistry letters

Published: October 21, 2022

System truncation accelerates binding affinity calculations with the fragment molecular orbital method: A benchmark study.

System truncation accelerates binding affinity calculations with the fragment molecular orbital method: A benchmark study.

Journal: Journal of computational chemistry

Published: August 07, 2022

Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602.

Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602.

Journal: Journal of virology

Published: January 19, 2022

Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.

Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: September 15, 2021

Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.

Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.

Journal: Bioorganic & medicinal chemistry

Published: April 13, 2021

Showing 1-8 of 8

Last Updated: 09/26/2026