Tess C. Lengyell
Vancouver, BC V6H0B3, Canada
Last Updated: 09/26/2026
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Found 11 publications
Humanized mice carrying a pathogenic GRN deletion as a pre-clinical platform for targeted gene therapies in frontotemporal dementia.
Journal: Neurobiology of disease
Published: March 06, 2026
First pilot study of intrastromal rAAV-PAX6 gene therapy suggests improved corneal thickness and transcription correction in aniridic mouse.
Journal: Molecular therapy. Advances
Published: November 13, 2025
First pilot study of intravenous rAAV-PAX6 gene therapy increases retinal-ganglion-cell-layer thickness and Notch1 transcription in a mouse model of aniridia.
Journal: Gene therapy
Published: August 13, 2025
Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.
Journal: Disease models & mechanisms
Published: February 01, 2024
ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons.
Journal: Ophthalmology and therapy
Published: March 12, 2023
A novel association between platelet filamin A and soluble N-ethylmaleimide sensitive factor attachment proteins regulates granule secretion.
Journal: Research and practice in thrombosis and haemostasis
Published: April 08, 2022
A novel mouse model for pyridoxine-dependent epilepsy due to antiquitin deficiency.
Journal: Human molecular genetics
Published: April 23, 2020
Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia.
Journal: Molecular therapy. Methods & clinical development
Published: February 19, 2020
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
Journal: eLife
Published: May 16, 2017
rAAV-compatible MiniPromoters for restricted expression in the brain and eye.
Journal: Molecular brain
Published: January 21, 2016
Showing 1-11 of 11
Last Updated: 09/26/2026