Tetsuo Cai

Tokyo, 1020083, Japan

Last Updated: 09/26/2026

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Found 11 publications

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.

Journal: eNeuro

Published: November 21, 2020

Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation.

Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation.

Journal: Journal of biochemistry

Published: May 18, 2020

Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH.

Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH.

Journal: Journal of biochemistry

Published: October 19, 2019

Structure-activity relationship of presenilin in γ-secretase-mediated intramembrane cleavage.

Structure-activity relationship of presenilin in γ-secretase-mediated intramembrane cleavage.

Journal: Seminars in cell & developmental biology

Published: September 23, 2019

Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase.

Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: April 06, 2019

Structural Analysis of Target Protein by Substituted Cysteine Accessibility Method.

Structural Analysis of Target Protein by Substituted Cysteine Accessibility Method.

Journal: Bio-protocol

Published: September 06, 2017

Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.

Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.

Journal: Journal of biochemistry

Published: September 04, 2017

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: June 11, 2017

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: January 29, 2016

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: February 13, 2015

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.

Journal: The Journal of biological chemistry

Published: December 01, 2014

Showing 1-11 of 11

Last Updated: 09/26/2026