Thomas B. Steinbrecher

Mannheim, BW 68163, Germany

Last Updated: 09/26/2026

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Found 38 publications

Selectride-Mediated Cleavage of 3-Picolyl and 3-Picolyloxycarbonyl Groups.

Selectride-Mediated Cleavage of 3-Picolyl and 3-Picolyloxycarbonyl Groups.

Journal: Organic letters
Published: June 26, 2026

Pharmacology of nivegacetor (RG6289), a potent and selective gamma secretase modulator in clinical development for the treatment of Alzheimer's disease.

Pharmacology of nivegacetor (RG6289), a potent and selective gamma secretase modulator in clinical development for the treatment of Alzheimer's disease.

Journal: Frontiers in pharmacology
Published: January 08, 2026

Performance of Relative Binding Free Energy Calculations on an Automatically Generated Dataset of Halogen-Deshalogen Matched Molecular Pairs.

Performance of Relative Binding Free Energy Calculations on an Automatically Generated Dataset of Halogen-Deshalogen Matched Molecular Pairs.

Journal: Journal of chemical information and modeling
Published: June 25, 2021

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.

Journal: Journal of chemical information and modeling
Published: August 20, 2020

Large-scale in vitro functional testing and novel variant scoring via protein modeling provide insights into alkaline phosphatase activity in hypophosphatasia.

Large-scale in vitro functional testing and novel variant scoring via protein modeling provide insights into alkaline phosphatase activity in hypophosphatasia.

Journal: Human mutation
Published: October 25, 2019

Best of Two Worlds? How MD Simulations of Amphiphilic Helical Peptides in Membranes Can Complement Data from Oriented Solid-State NMR.

Best of Two Worlds? How MD Simulations of Amphiphilic Helical Peptides in Membranes Can Complement Data from Oriented Solid-State NMR.

Journal: Journal of chemical theory and computation
Published: October 06, 2018

Thermodynamic integration network approach to ion transport through protein channels: Perspectives and limits.

Thermodynamic integration network approach to ion transport through protein channels: Perspectives and limits.

Journal: Journal of computational chemistry
Published: January 24, 2018

Validation of tautomeric and protomeric binding modes by free energy calculations. A case study for the structure based optimization of D-amino acid oxidase inhibitors.

Validation of tautomeric and protomeric binding modes by free energy calculations. A case study for the structure based optimization of D-amino acid oxidase inhibitors.

Journal: Journal of computer-aided molecular design
Published: October 04, 2017

Automated Transition State Search and Its Application to Diverse Types of Organic Reactions.

Automated Transition State Search and Its Application to Diverse Types of Organic Reactions.

Journal: Journal of chemical theory and computation
Published: September 29, 2017

Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study.

Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study.

Journal: Journal of chemical theory and computation
Published: January 20, 2017

Free Energy Perturbation Calculations of the Thermodynamics of Protein Side-Chain Mutations.

Free Energy Perturbation Calculations of the Thermodynamics of Protein Side-Chain Mutations.

Journal: Journal of molecular biology
Published: January 12, 2017

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.

Journal: Chem
Published: September 29, 2016
Showing 1-12 of 38

Last Updated: 09/26/2026