Thomas C. Pulinilkunnil

Halifax, NS, Canada

Last Updated: 09/26/2026

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Found 55 publications

TRPML1 signaling at lysosomes-mitochondria nexus drives triple-negative breast cancer mitophagy, metabolic reprogramming and chemoresistance.

TRPML1 signaling at lysosomes-mitochondria nexus drives triple-negative breast cancer mitophagy, metabolic reprogramming and chemoresistance.

Journal: bioRxiv : the preprint server for biology

Published: September 26, 2025

Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.

Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.

Journal: Circulation. Heart failure

Published: July 25, 2025

Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 overexpression on high-fat diet-induced cardiometabolic dysfunction in mice.

Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 overexpression on high-fat diet-induced cardiometabolic dysfunction in mice.

Journal: American journal of physiology. Heart and circulatory physiology

Published: January 13, 2025

Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer.

Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer.

Journal: Biochimica et biophysica acta. Molecular cell research

Published: September 17, 2024

Yap Is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates the Expression of Ctgf in Cardiomyocytes.

Yap Is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates the Expression of Ctgf in Cardiomyocytes.

Journal: Biomolecules

Published: September 10, 2024

Effect of (poly)phenol-rich 'Daux Belan' apple supplementation on diet-induced obesity and glucose intolerance in C57BL/6NCrl mice.

Effect of (poly)phenol-rich 'Daux Belan' apple supplementation on diet-induced obesity and glucose intolerance in C57BL/6NCrl mice.

Journal: Scientific reports

Published: June 12, 2023

Loss of transcription factor EB dysregulates the G1/S transition and DNA replication in mammary epithelial cells.

Loss of transcription factor EB dysregulates the G1/S transition and DNA replication in mammary epithelial cells.

Journal: The Journal of biological chemistry

Published: March 14, 2022

Nanoparticle surface-enhanced Raman spectroscopy as a noninvasive, label-free tool to monitor hematological malignancy.

Nanoparticle surface-enhanced Raman spectroscopy as a noninvasive, label-free tool to monitor hematological malignancy.

Journal: Nanomedicine (London, England)

Published: September 22, 2021

Whey peptides exacerbate body weight gain and perturb systemic glucose and tissue lipid metabolism in male high-fat fed mice.

Whey peptides exacerbate body weight gain and perturb systemic glucose and tissue lipid metabolism in male high-fat fed mice.

Journal: Food & function

Published: April 26, 2021

Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart.

Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart.

Journal: Metabolism: clinical and experimental

Published: April 18, 2021

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.

Journal: Cell death discovery

Published: April 09, 2021

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

Journal: Autophagy

Published: February 26, 2021

Showing 1-12 of 55

Last Updated: 09/26/2026