Thomas C. Garner

Internal Medicine

3780 Highway 17
Richmond Hill, GA 31324

Last Updated: 09/26/2026

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Found 6 publications

Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.

Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.

Journal: Journal of medicinal chemistry

Published: March 02, 2026

Optimization and In Vivo Characterization of a Series of Cbl‑b Inactive-State Inhibitors.

Optimization and In Vivo Characterization of a Series of Cbl‑b Inactive-State Inhibitors.

Journal: ACS medicinal chemistry letters

Published: February 20, 2026

Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated In Vivo Efficacy.

Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated In Vivo Efficacy.

Journal: ACS medicinal chemistry letters

Published: February 20, 2026

Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation.

Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation.

Journal: Nature

Published: April 30, 2025

Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.

Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.

Journal: Nature communications

Published: February 19, 2025

Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.

Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.

Journal: ACS medicinal chemistry letters

Published: February 06, 2024

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Last Updated: 09/26/2026