Thomas Fuchss

Frankfurter Str. 250
Darmstadt, HE 64293, Germany

Last Updated: 09/26/2026

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Found 14 publications

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 10, 2025

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 10, 2025

N,N-Bis(trifluoromethyl)aminoacetonitrile: A Versatile Building Block for the Introduction of the Bis(trifluoromethyl)amino Group.

N,N-Bis(trifluoromethyl)aminoacetonitrile: A Versatile Building Block for the Introduction of the Bis(trifluoromethyl)amino Group.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: April 25, 2025

Improving solubility by crystallographic disorder: Enabling Peposertib first-in-human trials.

Improving solubility by crystallographic disorder: Enabling Peposertib first-in-human trials.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: January 30, 2025

An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.

An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.

Journal: Angewandte Chemie (International ed. in English)

Published: June 26, 2024

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 05, 2023

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies.

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies.

Journal: Molecular cancer therapeutics

Published: November 25, 2021

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i).

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i).

Journal: Journal of medicinal chemistry

Published: July 06, 2021

Atropisomerism - A Neglected Way to Escape Out of Solubility Flatlands.

Atropisomerism - A Neglected Way to Escape Out of Solubility Flatlands.

Journal: Journal of pharmaceutical sciences

Published: June 22, 2021

Molecular basis of human ATM kinase inhibition.

Molecular basis of human ATM kinase inhibition.

Journal: Nature structural & molecular biology

Published: February 03, 2021

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.

Journal: Journal of chemical information and modeling

Published: August 20, 2020

Nitric Oxide Synthase Inhibitors into the Clinic at Last.

Nitric Oxide Synthase Inhibitors into the Clinic at Last.

Journal: Handbook of experimental pharmacology

Published: August 16, 2020

Showing 1-12 of 14

Last Updated: 09/26/2026