Thomas H. Keller

10 Biopolis Road
Chromos, 138670, Singapore

Last Updated: 09/26/2026

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Found 39 publications

Ultra-large scale virtual screening identifies a small molecule inhibitor of the Wnt transporter Wntless.

Ultra-large scale virtual screening identifies a small molecule inhibitor of the Wnt transporter Wntless.

Journal: iScience

Published: September 03, 2023

Structural model of human PORCN illuminates disease-associated variants and drug-binding sites.

Structural model of human PORCN illuminates disease-associated variants and drug-binding sites.

Journal: Journal of cell science

Published: September 16, 2021

Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase.

Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase.

Journal: Protein science : a publication of the Protein Society

Published: August 23, 2021

Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.

Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: July 16, 2021

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors*.

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors*.

Journal: Angewandte Chemie (International ed. in English)

Published: April 20, 2021

Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe.

Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe.

Journal: The Journal of experimental medicine

Published: December 14, 2020

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

Journal: Journal of medicinal chemistry

Published: January 08, 2020

Probing biological mechanisms with chemical tools.

Probing biological mechanisms with chemical tools.

Journal: Pharmacological research

Published: October 16, 2019

Correction to "Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3".

Correction to "Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3".

Journal: ACS medicinal chemistry letters

Published: August 16, 2019

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Journal: ACS medicinal chemistry letters

Published: April 15, 2019

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.

Journal: ACS medicinal chemistry letters

Published: November 12, 2018

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.

Journal: Molecular cancer therapeutics

Published: November 01, 2018

Showing 1-12 of 39

Last Updated: 09/26/2026