Thomas J. Cogswell

University Of Oxford Mansfield Road Oxford OX1 3TA UK
Oxford, ENG OX13TA, United Kingdom

Last Updated: 09/26/2026

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Found 10 publications

Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.

Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.

Journal: Journal of medicinal chemistry

Published: December 06, 2024

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Journal: RSC medicinal chemistry

Published: April 18, 2024

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

Journal: European journal of medicinal chemistry

Published: February 08, 2023

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.

Journal: iScience

Published: April 06, 2022

Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques.

Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques.

Journal: ACS medicinal chemistry letters

Published: November 14, 2021

A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo.

A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo.

Journal: Journal of medicinal chemistry

Published: October 21, 2021

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro.

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro.

Journal: Molecules (Basel, Switzerland)

Published: September 21, 2021

Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin.

Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin.

Journal: Beilstein journal of organic chemistry

Published: October 06, 2019

Flexible synthesis of polyfunctionalised 3-fluoropyrroles.

Flexible synthesis of polyfunctionalised 3-fluoropyrroles.

Journal: Organic & biomolecular chemistry

Published: November 12, 2015

Short and efficient synthesis of fluorinated δ-lactams.

Short and efficient synthesis of fluorinated δ-lactams.

Journal: Organic & biomolecular chemistry

Published: September 24, 2014

Showing 1-10 of 10

Last Updated: 09/26/2026