Thomas T. Macdonald
4 Newark St, Whitechapel
London, ENG E12AT, United Kingdom
London, ENG E12AT, United Kingdom
Last Updated: 09/26/2026
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Found 69 publications
Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease.
Journal: Scientific reports
Published: May 24, 2021
Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn's disease and ulcerative colitis patients.
Journal: Apoptosis : an international journal on programmed cell death
Published: April 19, 2021
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy.
Journal: Nature communications
Published: October 20, 2020
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
Journal: Communications biology
Published: November 07, 2019
Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.
Journal: Journal of inflammation research
Published: October 15, 2019
Editorial: Intestinal Homeostasis and Disease: A Complex Partnership Between Immune Cells, Non-Immune Cells, and the Microbiome.
Journal: Frontiers in immunology
Published: July 04, 2019
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
Journal: Journal of medicinal chemistry
Published: July 03, 2019
Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn's disease-related perianal fistula.
Journal: World journal of gastrointestinal pathophysiology
Published: April 30, 2019
Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients.
Journal: Scientific reports
Published: March 19, 2019
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Journal: Gut
Published: February 10, 2019
Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease.
Journal: PloS one
Published: January 11, 2019
IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.
Journal: The Journal of clinical investigation
Published: April 16, 2018
Last Updated: 09/26/2026