Tiina M. Sikanen

Helsinki, 00790, Finland

Last Updated: 09/26/2026

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Found 47 publications

In Vitro Liver Models for Studying Pharmaceutical Metabolism in Fish - A Critical Analysis of Their Applications and Limitations.

In Vitro Liver Models for Studying Pharmaceutical Metabolism in Fish - A Critical Analysis of Their Applications and Limitations.

Journal: Environmental science & technology

Published: May 27, 2026

Accounting for Differences in Plasma Protein Binding between Fish and Humans for Supporting Environmental Risk Assessment of Pharmaceuticals Using the Fish Plasma Model.

Accounting for Differences in Plasma Protein Binding between Fish and Humans for Supporting Environmental Risk Assessment of Pharmaceuticals Using the Fish Plasma Model.

Journal: Environmental science & technology

Published: April 21, 2026

Pan-continental assessment of socioeconomic and environmental predictors of PFAS occurrence in European rivers from a harmonised monitoring study.

Pan-continental assessment of socioeconomic and environmental predictors of PFAS occurrence in European rivers from a harmonised monitoring study.

Journal: Water research

Published: March 20, 2026

Greener active pharmaceutical ingredients: perspectives of European healthcare professionals.

Greener active pharmaceutical ingredients: perspectives of European healthcare professionals.

Journal: BMC health services research

Published: December 16, 2025

Patient-derived tumor organoids for personalized cancer immunotherapy: An immunopeptidome-to-validation approach in RCC and BC.

Patient-derived tumor organoids for personalized cancer immunotherapy: An immunopeptidome-to-validation approach in RCC and BC.

Journal: Molecular therapy. Oncology

Published: October 29, 2025

Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity.

Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity.

Journal: Nature communications

Published: August 27, 2025

Extending the shelf life of HLM chips through freeze-drying of human liver microsomes immobilized onto thiol-ene micropillar arrays.

Extending the shelf life of HLM chips through freeze-drying of human liver microsomes immobilized onto thiol-ene micropillar arrays.

Journal: Lab on a chip

Published: August 08, 2024

Comparative in vitro hepatic clearances of commonly used antidepressants, antipsychotics, and anti-inflammatory agents in rainbow trout liver S9 fractions.

Comparative in vitro hepatic clearances of commonly used antidepressants, antipsychotics, and anti-inflammatory agents in rainbow trout liver S9 fractions.

Journal: Aquatic toxicology (Amsterdam, Netherlands)

Published: March 25, 2024

Many human pharmaceuticals are weak inhibitors of the cytochrome P450 system in rainbow trout (Oncorhynchus mykiss) liver S9 fractions.

Many human pharmaceuticals are weak inhibitors of the cytochrome P450 system in rainbow trout (Oncorhynchus mykiss) liver S9 fractions.

Journal: Frontiers in toxicology

Published: March 25, 2024

Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact.

Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact.

Journal: Drug discovery today

Published: March 12, 2024

HLM chip - A microfluidic approach to study the mechanistic basis of cytochrome P450 inhibition using immobilized human liver microsomes.

HLM chip - A microfluidic approach to study the mechanistic basis of cytochrome P450 inhibition using immobilized human liver microsomes.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: January 10, 2024

Cytotoxicity of pharmaceuticals and their mixtures toward scaffold-free 3D spheroid cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes.

Cytotoxicity of pharmaceuticals and their mixtures toward scaffold-free 3D spheroid cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: December 31, 2023

Showing 1-12 of 47

Last Updated: 09/26/2026