Till A. Rohn

Basel, BS, Switzerland

Last Updated: 09/26/2026

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Found 19 publications

Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.

Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.

Journal: Nature communications
Published: June 30, 2025

Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

Journal: Journal of medicinal chemistry
Published: February 17, 2025

Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells.

Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Published: July 17, 2024

Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies.

Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies.

Journal: Nature communications
Published: May 14, 2024

Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.

Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.

Journal: Journal of medicinal chemistry
Published: March 13, 2024

Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds.

Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds.

Journal: Experimental dermatology
Published: November 30, 2023

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.

Journal: Journal of medicinal chemistry
Published: November 28, 2023

LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial.

LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial.

Journal: Clinical and translational science
Published: July 20, 2023

IL-26 Potentiates Type 2 Skin Inflammation in the Presence of IL-1β.

IL-26 Potentiates Type 2 Skin Inflammation in the Presence of IL-1β.

Journal: The Journal of investigative dermatology
Published: July 07, 2023

Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice.

Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice.

Journal: European journal of pharmacology
Published: December 12, 2022

Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa.

Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa.

Journal: The Journal of investigative dermatology
Published: March 09, 2022

Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors.

Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors.

Journal: Expert opinion on drug discovery
Published: June 30, 2021
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Last Updated: 09/26/2026