Tim M. Jonckers

Beerse, VLG, Belgium

Last Updated: 09/26/2026

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Found 27 publications

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

Journal: Journal of virology
Published: June 02, 2025

DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.

DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.

Journal: Journal of medicinal chemistry
Published: March 05, 2025

Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors.

Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors.

Journal: Journal of medicinal chemistry
Published: August 06, 2024

Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.

Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.

Journal: Journal of medicinal chemistry
Published: June 27, 2024

A Pangenotypic Hepatitis E Virus Replication Inhibitor With High Potency in a Rat Infection Model.

A Pangenotypic Hepatitis E Virus Replication Inhibitor With High Potency in a Rat Infection Model.

Journal: Gastroenterology
Published: June 14, 2024

Structure-Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors.

Structure-Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors.

Journal: ACS medicinal chemistry letters
Published: June 12, 2024

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.

Journal: Journal of medicinal chemistry
Published: March 14, 2024

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.

Journal: Communications biology
Published: August 07, 2023

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.

Journal: Journal of medicinal chemistry
Published: June 30, 2023

From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.

From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.

Journal: ACS medicinal chemistry letters
Published: August 10, 2022

Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.

Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.

Journal: Nature
Published: June 29, 2022

Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

Journal: Nature
Published: October 21, 2021
Showing 1-12 of 27

Last Updated: 09/26/2026