Timo Heinrich

Frankfurter Str. 250
Darmstadt, HE 64293, Germany

Last Updated: 09/26/2026

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Found 23 publications

Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.

Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.

Journal: Cancer letters

Published: November 18, 2025

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 10, 2025

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 10, 2025

Disrupting Notch signalling by a small molecule inhibiting dihydroorotate dehydrogenase activity.

Disrupting Notch signalling by a small molecule inhibiting dihydroorotate dehydrogenase activity.

Journal: Scientific reports

Published: October 23, 2025

CNS penetrant TEAD1,2,4 inhibitor MSC-4070 derived from phenotypic screening hit optimization.

CNS penetrant TEAD1,2,4 inhibitor MSC-4070 derived from phenotypic screening hit optimization.

Journal: RSC medicinal chemistry

Published: October 16, 2025

Synthesis of Sulfondiimidoates by Desoxychlorination of Sulfonimidamides.

Synthesis of Sulfondiimidoates by Desoxychlorination of Sulfonimidamides.

Journal: Organic letters

Published: October 03, 2025

MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.

MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.

Journal: Journal of medicinal chemistry

Published: December 20, 2024

Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold.

Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold.

Journal: Bioorganic & medicinal chemistry letters

Published: July 21, 2024

MCT4 blockade increases the efficacy of immune checkpoint blockade.

MCT4 blockade increases the efficacy of immune checkpoint blockade.

Journal: Journal for immunotherapy of cancer

Published: September 18, 2023

Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.

Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.

Journal: Biosensors

Published: August 20, 2023

Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction.

Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction.

Journal: Biochemical pharmacology

Published: June 17, 2023

Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.

Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.

Journal: Molecular cancer therapeutics

Published: February 15, 2023

Showing 1-12 of 23

Last Updated: 09/26/2026