Timo T. Myohanen

Helsinki, Finland

Last Updated: 09/26/2026

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Found 44 publications

Novel PREP ligand, HUP-46, ameliorates behavioral deficits in an alpha-synuclein based Parkinson's disease model.

Novel PREP ligand, HUP-46, ameliorates behavioral deficits in an alpha-synuclein based Parkinson's disease model.

Journal: Experimental neurology

Published: September 12, 2025

A prolyl oligopeptidase ligand blocks memory deficit in a repeated mild traumatic brain injury model.

A prolyl oligopeptidase ligand blocks memory deficit in a repeated mild traumatic brain injury model.

Journal: Experimental neurology

Published: May 30, 2025

5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.

5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.

Journal: Journal of medicinal chemistry

Published: March 28, 2024

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.

Journal: Journal of medicinal chemistry

Published: May 29, 2023

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.

Journal: Science translational medicine

Published: April 12, 2023

Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon.

Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon.

Journal: Neurobiology of aging

Published: February 08, 2023

Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.

Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.

Journal: Neuropharmacology

Published: June 28, 2022

Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy.

Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy.

Journal: Biochemical pharmacology

Published: October 20, 2021

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration.

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: October 05, 2021

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors.

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors.

Journal: ACS medicinal chemistry letters

Published: July 21, 2021

Multiplexed analysis of amino acids in mice brain microdialysis samples using isobaric labeling and liquid chromatography-high resolution tandem mass spectrometry.

Multiplexed analysis of amino acids in mice brain microdialysis samples using isobaric labeling and liquid chromatography-high resolution tandem mass spectrometry.

Journal: Journal of chromatography. A

Published: May 27, 2021

Deletion or inhibition of prolyl oligopeptidase blocks lithium-induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A.

Deletion or inhibition of prolyl oligopeptidase blocks lithium-induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A.

Journal: Basic & clinical pharmacology & toxicology

Published: May 03, 2021

Showing 1-12 of 44

Last Updated: 09/26/2026