Last Updated: 09/26/2026
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Found 4 publications
Hemangiosarcoma in mice administered pregabalin: analysis of genotoxicity, tumor incidence, and tumor genetics.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: April 28, 2012
Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: April 28, 2012
Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: April 28, 2012
Pregabalin induces hepatic hypoxia and increases endothelial cell proliferation in mice, a process inhibited by dietary vitamin E supplementation.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: April 28, 2012
Showing 1-4 of 4
Last Updated: 09/26/2026