Tohru Hirato
Kobe, 6512241, Japan
Last Updated: 09/26/2026
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Found 16 publications
Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice.
Journal: Molecular pharmaceutics
Published: October 20, 2023
α-L-iduronidase fused with humanized anti-human transferrin receptor antibody (lepunafusp alfa) for mucopolysaccharidosis type I: A phase 1/2 trial.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: October 10, 2023
Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice.
Journal: Molecular therapy. Methods & clinical development
Published: February 16, 2023
Pathogenic Roles of Heparan Sulfate and Its Use as a Biomarker in Mucopolysaccharidoses.
Journal: International journal of molecular sciences
Published: September 07, 2022
Pharmacokinetics and pharmacodynamics of once-weekly administration of JR-142, a long-acting albumin-fused human growth hormone: A rondemized, placebo-controlled phase 1 study.
Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Published: April 14, 2022
Dose-dependent effects of a brain-penetrating iduronate-2-sulfatase on neurobehavioral impairments in mucopolysaccharidosis II mice.
Journal: Molecular therapy. Methods & clinical development
Published: February 17, 2022
Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II.
Journal: Molecular genetics and metabolism reports
Published: April 12, 2021
Clearance of heparan sulfate in the brain prevents neurodegeneration and neurocognitive impairment in MPS II mice.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: August 16, 2020
Physicochemical and biological evaluation of JR-131 as a biosimilar to a long-acting erythropoiesis-stimulating agent darbepoetin alfa.
Journal: PloS one
Published: December 25, 2019
Iduronate-2-Sulfatase with Anti-human Transferrin Receptor Antibody for Neuropathic Mucopolysaccharidosis II: A Phase 1/2 Trial.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: September 20, 2018
Non-clinical evaluation of JR-051 as a biosimilar to agalsidase beta for the treatment of Fabry disease.
Journal: Molecular genetics and metabolism
Published: July 17, 2018
A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: December 14, 2017
Last Updated: 09/26/2026