Tom H. Johnston

60 Leonard Ave
Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 29 publications

A small molecule reduces both parkinsonism and l-dopa-induced dyskinesia in animal models of Parkinson's disease.

A small molecule reduces both parkinsonism and l-dopa-induced dyskinesia in animal models of Parkinson's disease.

Journal: Science translational medicine
Published: July 15, 2026

Using artificial intelligence to identify drugs for repurposing to treat l-DOPA-induced dyskinesia.

Using artificial intelligence to identify drugs for repurposing to treat l-DOPA-induced dyskinesia.

Journal: Neuropharmacology
Published: June 14, 2023

Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases.

Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases.

Journal: EJNMMI research
Published: March 30, 2022

A novel dopamine D3R agonist SK609 with norepinephrine transporter inhibition promotes improvement in cognitive task performance in rodent and non-human primate models of Parkinson's disease.

A novel dopamine D3R agonist SK609 with norepinephrine transporter inhibition promotes improvement in cognitive task performance in rodent and non-human primate models of Parkinson's disease.

Journal: Experimental neurology
Published: August 12, 2020

The selective 5-HT1A receptor agonist, NLX-112, exerts anti-dyskinetic effects in MPTP-treated macaques.

The selective 5-HT1A receptor agonist, NLX-112, exerts anti-dyskinetic effects in MPTP-treated macaques.

Journal: Parkinsonism & related disorders
Published: June 02, 2020

NYX-458 Improves Cognitive Performance in a Primate Parkinson's Disease Model.

NYX-458 Improves Cognitive Performance in a Primate Parkinson's Disease Model.

Journal: Movement disorders : official journal of the Movement Disorder Society
Published: September 16, 2019

Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson's Disease.

Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson's Disease.

Journal: The Journal of pharmacology and experimental therapeutics
Published: December 06, 2018

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.

Journal: Movement disorders : official journal of the Movement Disorder Society
Published: October 17, 2018

Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease.

Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease.

Journal: Neuropharmacology
Published: April 05, 2018

Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia.

Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia.

Journal: The Journal of pharmacology and experimental therapeutics
Published: January 03, 2018

DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease.

DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease.

Journal: Neuropharmacology
Published: June 16, 2017

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque.

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque.

Journal: PloS one
Published: June 27, 2016
Showing 1-12 of 29

Last Updated: 09/26/2026