Tomas Smutny

Hradec Kralove, KR 50005, Czech Republic

Last Updated: 09/26/2026

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Found 33 publications

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone-Binding Globulin Expression.

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone-Binding Globulin Expression.

Journal: Basic & clinical pharmacology & toxicology

Published: September 01, 2025

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation.

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation.

Journal: Journal of medicinal chemistry

Published: July 12, 2025

LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver.

LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver.

Journal: Molecular pharmacology

Published: August 14, 2024

Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids.

Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids.

Journal: PLoS computational biology

Published: July 09, 2024

Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes.

Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes.

Journal: Biochemical pharmacology

Published: May 12, 2024

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.

Journal: Nature communications

Published: March 31, 2024

Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.

Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.

Journal: EJNMMI radiopharmacy and chemistry

Published: February 09, 2024

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.

Journal: Journal of medicinal chemistry

Published: February 09, 2023

Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes.

Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes.

Journal: Molecular nutrition & food research

Published: January 27, 2022

Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.

Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.

Journal: Archives of toxicology

Published: June 23, 2021

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.

Journal: Cells

Published: August 17, 2020

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.

Journal: Archives of toxicology

Published: July 01, 2020

Showing 1-12 of 33

Last Updated: 09/26/2026