Tomasz Rzymski

Krakow, MA 30394, Poland

Last Updated: 09/26/2026

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Found 21 publications

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML.

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML.

Journal: Cells

Published: June 28, 2026

Romaciclib, a CDK8/CDK19 inhibitor, can overcome venetoclax resistance through a combinatorial strategy.

Romaciclib, a CDK8/CDK19 inhibitor, can overcome venetoclax resistance through a combinatorial strategy.

Journal: bioRxiv : the preprint server for biology

Published: December 25, 2025

Dual FLT3/PIM inhibitor dapolsertib in acute myeloid leukemia: results from the phase 1/2 DIAMOND-01 trial.

Dual FLT3/PIM inhibitor dapolsertib in acute myeloid leukemia: results from the phase 1/2 DIAMOND-01 trial.

Journal: Blood neoplasia

Published: April 07, 2025

Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer.

Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer.

Journal: Scientific reports

Published: March 11, 2025

Transcriptional Regulation of Protein Synthesis by Mediator Kinase Represents a Therapeutic Vulnerability in MYC-driven Medulloblastoma.

Transcriptional Regulation of Protein Synthesis by Mediator Kinase Represents a Therapeutic Vulnerability in MYC-driven Medulloblastoma.

Journal: Research square

Published: November 22, 2024

Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma.

Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma.

Journal: Nature communications

Published: October 24, 2024

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.

Journal: The Journal of clinical investigation

Published: May 01, 2024

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

Journal: The Journal of clinical investigation

Published: April 15, 2024

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma.

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma.

Journal: bioRxiv : the preprint server for biology

Published: April 01, 2024

Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.

Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.

Journal: International journal of molecular sciences

Published: August 17, 2021

Potential of enhancer of zeste homolog 2 inhibitors for the treatment of SWI/SNF mutant cancers and tumor microenvironment modulation.

Potential of enhancer of zeste homolog 2 inhibitors for the treatment of SWI/SNF mutant cancers and tumor microenvironment modulation.

Journal: Drug development research

Published: November 10, 2020

Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.

Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.

Journal: European journal of medicinal chemistry

Published: September 11, 2020

Showing 1-12 of 21

Last Updated: 09/26/2026