Tomohiro Ohashi

Fujisawa, 2518555, Japan

Last Updated: 09/26/2026

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Found 13 publications

Photoredox-based late-stage functionalization in SAR study for in vivo potent glucosylceramide synthase inhibitor.

Photoredox-based late-stage functionalization in SAR study for in vivo potent glucosylceramide synthase inhibitor.

Journal: Bioorganic & medicinal chemistry letters

Published: September 13, 2022

Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore.

Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore.

Journal: Journal of medicinal chemistry

Published: February 21, 2022

Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain.

Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain.

Journal: Journal of medicinal chemistry

Published: August 04, 2021

Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.

Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.

Journal: PloS one

Published: January 06, 2020

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

Journal: Nature communications

Published: June 13, 2016

Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.

Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.

Journal: Bioorganic & medicinal chemistry

Published: April 01, 2015

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: December 23, 2012

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.

Journal: Bioorganic & medicinal chemistry

Published: June 13, 2012

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: May 25, 2012

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

Journal: Bioorganic & medicinal chemistry

Published: May 25, 2012

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.

Journal: Bioorganic & medicinal chemistry

Published: April 25, 2012

Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.

Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.

Journal: Journal of medicinal chemistry

Published: March 24, 2012

Showing 1-12 of 13

Last Updated: 09/26/2026