Tomomi Yachide-Noguchi

The University Of Tokyo 1-1-1 Yayoi Bunkyo Ku Tokyo 113-0032 Japan
Tokyo, 1130032, Japan

Last Updated: 09/26/2026

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Found 20 publications

Physicochemical characterization of B-hydroxyphenyl phosphine borane derivatives and their evaluation as nuclear estrogen receptor ligands.

Physicochemical characterization of B-hydroxyphenyl phosphine borane derivatives and their evaluation as nuclear estrogen receptor ligands.

Journal: RSC medicinal chemistry

Published: July 19, 2023

Design, synthesis and structure-activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists.

Design, synthesis and structure-activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists.

Journal: Bioorganic & medicinal chemistry

Published: April 08, 2022

Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs.

Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs.

Journal: PloS one

Published: April 20, 2020

Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton.

Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton.

Journal: Bioorganic & medicinal chemistry

Published: February 08, 2019

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton.

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton.

Journal: Bioorganic & medicinal chemistry

Published: January 15, 2018

Synthesis and evaluation of novel dual BRD4/HDAC inhibitors.

Synthesis and evaluation of novel dual BRD4/HDAC inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: April 07, 2017

Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein.

Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein.

Journal: Bioorganic & medicinal chemistry letters

Published: April 03, 2017

Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.

Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.

Journal: Bioorganic & medicinal chemistry letters

Published: February 21, 2017

Structure-Activity Relationship Study of N(6)-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-α Production.

Structure-Activity Relationship Study of N(6)-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-α Production.

Journal: Chemical & pharmaceutical bulletin

Published: September 02, 2016

Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.

Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.

Journal: Bioorganic & medicinal chemistry

Published: August 09, 2016

Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.

Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.

Journal: Bioorganic & medicinal chemistry

Published: July 22, 2016

BET Bromodomain as a Target of Epigenetic Therapy.

BET Bromodomain as a Target of Epigenetic Therapy.

Journal: Chemical & pharmaceutical bulletin

Published: June 03, 2016

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Last Updated: 09/26/2026