Tomoyuki Ohe

Minato, 1058512, Japan

Last Updated: 09/26/2026

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Found 36 publications

KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation.

KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation.

Journal: Cellular signalling

Published: July 14, 2025

Development of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2-acetamide Scaffold, and its Anti-Inflammatory Effects.

Development of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2-acetamide Scaffold, and its Anti-Inflammatory Effects.

Journal: ChemMedChem

Published: June 09, 2025

Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates.

Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates.

Journal: Drug metabolism and pharmacokinetics

Published: November 13, 2022

Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease.

Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease.

Journal: Bioorganic & medicinal chemistry letters

Published: October 01, 2022

Formation of reactive metabolites of benzbromarone in humanized-liver mice.

Formation of reactive metabolites of benzbromarone in humanized-liver mice.

Journal: Drug metabolism and pharmacokinetics

Published: March 29, 2022

Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells.

Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells.

Journal: International journal of molecular sciences

Published: December 17, 2021

Development of a Fluorescent-Labeled Trapping Reagent to Detect Reactive Acyl Glucuronides.

Development of a Fluorescent-Labeled Trapping Reagent to Detect Reactive Acyl Glucuronides.

Journal: Chemical research in toxicology

Published: October 27, 2021

Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation.

Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation.

Journal: Drug metabolism and pharmacokinetics

Published: September 29, 2021

A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells.

A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells.

Journal: European journal of pharmacology

Published: September 20, 2021

A pyridinium‑type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of β‑catenin.

A pyridinium‑type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of β‑catenin.

Journal: Oncology reports

Published: August 29, 2021

Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase.

Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase.

Journal: Bioorganic & medicinal chemistry letters

Published: April 23, 2021

Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites.

Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites.

Journal: Drug metabolism and pharmacokinetics

Published: November 18, 2020

Showing 1-12 of 36

Last Updated: 09/26/2026