Torsten Hoffmann

Dortmund, NW 44227, Germany

Last Updated: 09/26/2026

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Found 17 publications

Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety.

Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety.

Journal: Molecular metabolism

Published: March 03, 2023

Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice.

Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice.

Journal: International journal of molecular sciences

Published: September 06, 2021

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach.

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach.

Journal: Journal of medicinal chemistry

Published: June 02, 2021

Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets.

Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets.

Journal: Cell chemical biology

Published: July 24, 2020

Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering.

Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering.

Journal: Angewandte Chemie (International ed. in English)

Published: June 18, 2020

The next level in chemical space navigation: going far beyond enumerable compound libraries.

The next level in chemical space navigation: going far beyond enumerable compound libraries.

Journal: Drug discovery today

Published: November 19, 2018

N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.

N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.

Journal: Bioscience reports

Published: March 17, 2017

Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy.

Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy.

Journal: The Journal of pharmacology and experimental therapeutics

Published: February 07, 2017

Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.

Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.

Journal: Alzheimer's research & therapy

Published: January 26, 2017

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.

Journal: Alzheimer's & dementia (New York, N. Y.)

Published: October 03, 2015

Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation.

Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation.

Journal: Neuropeptides

Published: September 28, 2015

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.

Journal: Biological chemistry

Published: June 10, 2015

Showing 1-12 of 17

Last Updated: 09/26/2026